University of Sheffield Back to Nick Fieller's homepageDepartment of Probability and Statistics

Medical Statistics

The material on this page originated in an MSc/final year undergrauate course on Medical Statistics. After reliquishing the course I am consolidating the lecture notes into a more convenient form, incorporating the simple and more substantial exercises (and solutions) into the main body of the text at appropriate places. Material which was originally only mentioned in the lecture slides will be contained in the main body of the text. For the time being I have left handout copies of the original lecture slides and links to recordings of the lectures made with the Echo360 system in Autumn 2011. The material is in .pdf form and may be read and printed with Adobe Acrobat. The data sets are in R, Minitab, SPSS, SAS or S-plus form as indicated. It is recommended that you use Microsoft Internet Explorer or Chrome to access these, clicking on them gives the option of downloading or running from the web sources. Downloading is recommended and is necessary for R data sets.

The computer package for the course is R. A brief introduction to R is given here. More information is given on the CRAN home page.

Clinical Trials (0.65MB)
Survival Analysis (0.65MB)

RSS feed Click here for links to lecture podcasts, vodcasts and rich media recordings of lectures.

The notes are given in a complete Acrobat .pdf file with a hot-linked table of contents immediately following the title page.
To print just one of the chapters note that the printed pages numbers in the contents list and in the notes do not correspond with those of the .pdf file. Instead, use the contents list to move to the start of the chapter and note the page number given at the bottom of the Acrobat window. This will allow you to issue a print instruction for the appropriate number of pages starting at that point.

Clinical Trials: Lecture Slides, Sections 0 to 2
Clinical Trials: Lecture Slides, Sections 3 to 4
Clinical Trials: Lecture Slides, Section 5
Clinical Trials: Lecture Slides, Section 6
Clinical Trials: Lecture Slides, Section 7
Clinical Trials: Lecture Slides, Section 8
Clinical Trials: Lecture Slides, Section 9
Clinical Trials: Lecture Slides, Section 10

Survival Analysis: Lecture Slides, Sections 0 to 2.5
Survival Analysis: Lecture Slides, Sections 2.6 to 2.7
Survival Analysis: Lecture Slides, Chapter 3
Survival Analysis: Lecture Slides, Chapter 4

Additional Informal Lecture notes:

Sample size tips

Neave's table tips

Revision of hypothesis tests

R Script Files for Task Sheets and Exercises etc:

Clinical Task Sheet 2 etc       Clinical Task Sheet 4 etc
Clinical Task Sheet 5 etc
Survival Task Sheet 1-3 etc Survival Task Sheet 5 etc
Medical Exercises 1 Medical Exercises 2
braintu.R lymphoma.R
methtrex.R leukrem.R
AHprostate

     

Past Exam Papers

Copies of previous exam papers are available here.

Rubric and Allowed material in open book examinations

The rubric on the examination papers is
RESTRICTED OPEN BOOK EXAMINATION.
Candidates may bring to the examination lecture notes and associated lecture material (but no textbooks) plus a calculator that conforms to University regulations. All answers will be marked but credit will be given for only the best THREE answers.
All questions carry equal marks. Total marks 99.
(NB: The total marks in the case of the PAS461 examination is 75).
Definition of "lecture notes and associated lecture material": This consists of anything that you have downloaded and printed from this course page, including example sheets and solutions, examination papers and solutions to the past two years' of examination papers (i.e. for 2010/11 and 2011/12 ONLY) together with any personal notes you have made and any annotations you have personally made on material printed from this course page and any material distributed in the MAS361/461 lectures. It does not include any material printed from other module pages nor any examination papers and solutions for years other than the previous two years nor any text books (even if listed as recommended texts within the course material).

Solutions to past exam papers:

Brian Everitt's Data Sets and Functions:

Click here to access Brian Everitt's webpage containing functions and data sets
from his book (with Sophie Rabe-Hesketh) Analyzing Medical Data Using S-PLUS.

Download Data Sets:

R data sets

NB: you should save R.data files to your hard disk by right-clicking
and choosing "Save Target As...".
Do not try to open them from the web page.

All R.data sets (zip file)

Survival times of spoons

Tumour remission times

Liver cirrhosis data

Lung cancer survival times

Hours Sleep

Brain tumour survival times times

Leukaemia remission times

Prostatic cancer survival

AHProstate cancer survival

lymphoma survival

Australian spoons

methtrex survival

Description of methtrex data set (pdf)

Other Formats

Hours Sleep (Minitab)

Hours Sleep (S-PLUS)

Tumour remission times (Minitab)

Tumour remission times (S-PLUS)

Tumour remission times (SPSS)

Lung cancer survival times (Minitab)

Lung cancer survival times (S-PLUS)

Lung cancer survival times (SPSS)

Brain tumour survival times (Minitab)

Brain tumour survival times times (S-PLUS)

Brain tumour survival times times (SPSS)

Leukaemia remission times (Minitab)

Leukaemia remission times (S-PLUS)

Leukaemia remission times (SPSS)

Prostatic cancer survival times (Minitab)

Prostatic cancer survival (S-PLUS)

Prostatic cancer survival (SPSS)

lymphoma survival times (Minitab)

lymphoma survival (S-PLUS)

lymphoma survival (SPSS)

Description of methtrex data set (pdf)

methtrex survival times (Minitab)

methtrex survival (S-PLUS)

methtrex survival (SPSS)

methtrex survival (Excel)

Links:

Click here for Ben Goldacre's Bad Science page

Click here for the NHS Behind the Headlines pages

Click here for link to the British Medical Journal

Click here for sample size programmes.

Click here for the registry of clinical trials.

Click here for PubMed.

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This page is maintained by Dr Nick Fieller and was last updated on 11/09/2011.